2025 年第 1 期 第 20 卷

γ-氨基丁酸A型受体相关蛋白1介导自噬在胃癌中作用的研究进展

Research progress on the role of γ-aminobutyric acid type A receptor-associated protein like 1 mediated autophagy in gastric cancer

作者：王婷婷  郭静  常宇  马军伟  冯蓓  胡云峰

英文作者：Wang Tingting Guo Jing Chang Yu Ma Junwei Feng Bei Hu Yunfeng

单位：延安大学附属医院放射治疗科，延安716000 王婷婷为延安大学2022级放射肿瘤学专业在读研究生

英文单位：Department of Radiotherapy Yan′an University Affiliated Hospital Yan′an 716000 China Wang Tingting is a graduate student majoring in radiation oncology for the class of 2022 at Yan′an University

关键词：胃癌；  GABAA型受体相关蛋白1；  自噬

英文关键词：Gastriccancer;  γ-aminobutyricacidtypeAreceptorassociatedproteinlike1;  Autophagy

• 摘要：

• 胃癌是消化道中常见的恶性肿瘤之一，是全球癌症相关的主要死因之一。化疗是晚期胃癌的常规治疗方法，而化疗耐药性是胃癌预后不良的重要原因。自噬是一种高度保守的代谢过程，自噬调控胃癌的发展与化疗耐药性。γ-氨基丁酸A型受体相关蛋白1（GABARAPL1）是一种泛素样蛋白，在自噬过程中起重要作用，微小RNA/长链非编码RNA/环状RNA-GABARAPL1轴可能是胃癌发展、化疗耐药的关键机制。本文就GABARAPL1调控自噬的机制及其对胃癌发展、化疗耐药性的研究进展作一综述，以期为胃癌治疗提供新的思路。

•  Gastric cancer is one of the most common malignant tumors in the digestive tract and is one of the leading causes of cancer-related death worldwide. Chemotherapy is the conventional treatment for advanced gastric cancer, and chemoresistance is an important reason for the poor prognosis of gastric cancer. Autophagy is a highly conserved metabolic process, which regulates the development and chemoresistance of gastric cancer.γ-aminobutyric acid type A receptor associated protein like 1 (GABARAPL1) is a ubiquitin-like protein that plays an important role in autophagy. The axis of microRNA/long non-coding RNA/circular RNA-GABARAPL1 may play a key role in the development and chemoresistance of gastric cancer. In this review, the mechanism of autophagy regulated by GABARAPL1 and its role in the development and chemoresistance of gastric cancer are summarized in order to provide new ideas for the treatment of gastric cancer.