2025 年第 2 期 第 20 卷

血清血红素加氧酶1联合Essen卒中风险评分对孤立性眩晕患者并发脑梗死的预测效能

Predictive efficacy of serum heme oxygenase-1 combined with Essen stroke risk score in patients with isolated vertigo complicated with cerebral infarction

作者：杨春艳李田郑雪姣

英文作者：Yang Chunyan Li Tian Zheng Xuejiao

单位：西安交通大学第一附属医院榆林医院神经内科，榆林719000

英文单位：Department of Neurology the First Affiliated Hospital of Xi′an Jiaotong University Yulin Hospital Yulin 719000 China

关键词：孤立性眩晕；脑梗死；血红素加氧酶1；Essen卒中风险评分；预测效能

英文关键词：Isolatedvertigo;Cerebralinfarction;Hemeoxygenase-1;Essenstrokeriskscore;Predictiveefficacy

• 摘要：

• 目的 探讨血红素加氧酶1（HO-1）联合Essen卒中风险评分（ESRS）对孤立性眩晕患者并发脑梗死的预测效能。方法 选取2022年2月至2024年2月西安交通大学第一附属医院榆林医院收治的163例孤立性眩晕患者作为研究对象，依据其脑梗死发生情况分为发生组（47例）和未发生组（116例）。对比2组基线资料，比较2组HO-1水平和ESRS，多因素Logistic回归分析孤立性眩晕患者并发脑梗死的影响因素，受试者工作特征曲线分析HO-1联合ESRS对孤立性眩晕患者并发脑梗死的预测效能。结果 发生组高血压病比例、白细胞介素6（IL-6）水平显著高于未发生组，差异均有统计学意义（均P＜0.05）。发生组HO-1水平显著低于未发生组［（102±20）μg/L比（240±35）μg/L］，ESRS显著高于未发生组［（5.5±2.1）分比（3.1±1.1）分］，差异均有统计学意义（均P＜0.001）。多因素Logistic回归分析结果显示，合并高血压病、IL-6水平升高、ESRS升高均为孤立性眩晕患者并发脑梗死的独立危险因素，HO-1降低为孤立性眩晕患者并发脑梗死风险的独立保护因素（均P＜0.001）。HO-1、ESRS联合检测预测孤立性眩晕患者并发脑梗死的敏感度和特异度分别为89.36%、87.07%，二者联合的曲线下面积显著大于单一检测（均P＜0.05）。结论 孤立性眩晕并发脑梗死患者HO-1水平显著降低，ESRS显著升高，HO-1联合ESRS对孤立性眩晕患者并发脑梗死具有较高预测效能。

• Objective To investigate the efficacy of heme oxygenase-1 (HO-1) combined with Essen stroke risk score (ESRS) in predicting cerebral infarction in patients with isolated vertigo. Methods A total of 163 patients with isolated vertigo admitted to the First Affiliated Hospital of Xi′an Jiaotong University Yulin Hospital from February 2022 to February 2024 were selected as the research objects. According to the occurrence of cerebral infarction, they were divided into occurrence group (47 cases) and non-occurrence group (116 cases). The baseline data of the two groups were compared, and the levels of HO-1 and ESRS were compared between the two groups. Multivariate Logistic regression analysis was used to analyze the influencing factors of cerebral infarction in patients with isolated vertigo. The receiver operating characteristic curve was used to analyze the predictive efficacy of HO-1 combined with ESRS in patients with isolated vertigo complicated with cerebral infarction. Results The proportion of hypertension and the level of interleukin-6 (IL-6) were significantly higher in the occurrence group than those in the non-occurrence group (both P＜0.05). The level of HO-1 in the occurrence group was significantly lower than that in the non-occurrence group［(102±20)μg/L vs (240±35)μg/L］, and the ESRS was significantly higher than that in the non-occurrence group［(5.5±2.1) vs (3.1±1.1)］(both P＜0.001). Multivariate Logistic regression analysis showed that hypertension, increased levels of IL-6 and ESRS were independent risk factors for cerebral infarction in patients with isolated vertigo, and low level of HO-1 was an independent protective factor for cerebral infarction in patients with isolated vertigo (all P＜0.001). The sensitivity and specificity of the combined detection of HO-1 and ESRS in the diagnosis of cerebral infarction in patients with isolated vertigo were 89.36% and 87.07%, respectively, and the area under the curve of the combined detection of HO-1 and ESRS was significantly greater than those of the single detection (both P < 0.05). Conclusion The level of HO-1 in patients with isolated vertigo complicated with cerebral infarction is significantly decreased, and the ESRS is significantly increased. The combination of HO-1 and ESRS has a high predictive value for the diagnosis of isolated vertigo complicated with cerebral infarction.