2025 年第 8 期 第 20 卷

参桂胶囊联合沙库巴曲缬沙坦钠治疗慢性心力衰竭的效果及对血清血管紧张素Ⅱ和B型脑钠肽水平的影响

The effect of Shengui capsule combined with sacubitril/valsartan sodium in the treatment of chronic heart failure and its influence on serum angiotensin Ⅱ and brain natriuretic peptide levels

作者：梁肖倩1张继伟2刘红涛3

英文作者：Liang Xiaoqian1 Zhang Jiwei2 Liu Hongtao3

单位：1河北省胸科医院心内科，石家庄050000；2河北大学附属医院心血管内科，保定071000；3河北省定州市人民医院心内三科，定州073000

英文单位：1Department of Cardiology Hebei Chest Hospital Shijiazhuang 050000 China; 2Department of Cardiovascular Medicine Hebei University Affiliated Hospital Baoding 071000 China; 3Third Department of Cardiology Dingzhou People′s Hospital Hebei Province Dingzhou 073000 China

关键词：慢性心力衰竭；参桂胶囊；沙库巴曲缬沙坦钠；心功能；氧化应激

英文关键词：Chronicheartfailure;Shenguicapsule;Sacubitril/valsartansodium;Cardiacfunction; Oxidativestress

• 摘要：

• 目的 探究参桂胶囊联合沙库巴曲缬沙坦钠治疗慢性心力衰竭的临床效果及对血清血管紧张素Ⅱ（AngⅡ）、B型脑钠肽（BNP）水平的影响。方法 选取河北省胸科医院2023年7月至2024年5月收治的128例慢性心力衰竭患者，采用简单随机法分为单药组和联合组，各64例。单药组给予沙库巴曲缬沙坦钠治疗，联合组在单药组基础上联合参桂胶囊治疗。比较2组的治疗效果、AngⅡ、BNP、心功能、氧化应激水平及Lee氏心力衰竭积分、心力衰竭自我护理指数（SCHFI）评分情况。结果  治疗后，联合组总有效率高于单药组［92.2%（59/64）比78.1%（50/64）］（P=0.025）。治疗后，2组血清AngⅡ、BNP水平均低于治疗前，且联合组均低于单药组［（25.1±2.7）ng/L比（28.7±3.0）ng/L、（143±15）ng/L比（169±17）ng/L］（均P<0.05）。治疗后，2组左心室射血分数、超氧化物歧化酶、谷胱甘肽过氧化物酶、SCHFI评分均高于治疗前，且联合组均高于单药组（均P<0.05），2组左心室后壁厚度、丙二醛水平、Lee氏心力衰竭积分均低于治疗前，且联合组均低于单药组（均P<0.05）。结论  参桂胶囊联合沙库巴曲缬沙坦钠治疗慢性心力衰竭效果较好，有效提升心功能，改善呼吸困难等症状。

• Objective To investigate the clinical effect of Shengui capsule combined with sacubitril/valsartan sodium in the treatment of chronic heart failure and its effect on serum angiotensin Ⅱ (AngⅡ) and brain natriuretic peptide (BNP) levels. Methods A total of 128 patients with chronic heart failure admitted to Hebei Chest Hospital from July 2023 to May 2024 were selected. They were divided into single drug group and combined group by simple random method, with 64 cases in each group. The single drug group was treated with sacubitril/valsartan sodium, and the combined group was treated with Shengui capsule on the basis of the single drug group. The treatment effect, AngⅡ, BNP, cardiac function, oxidative stress level, Lee′s heart failure score and heart failure self-care index (SCHFI) score were compared between the two groups. Results After treatment, the total effective rate of the combined group was higher than that of the single drug group ［92.2%(59/64) vs 78.1%(50/64)］ (P=0.025). After treatment, the serum levels of AngⅡ and BNP in the two groups were lower than those before treatment, and those in the combined group were lower than those in the single drug group ［(25.1±2.7)ng/L vs (28.7±3.0)ng/L, (143±15)ng/L vs (169±17)ng/L］(all P<0.05). After treatment, the left ventricular ejection fraction, superoxide dismutase, glutathione peroxidase and SCHFI score of the two groups were higher than those before treatment, and those of the combined group were higher than those of the single drug group (all P<0.05). The left ventricular posterior wall thickness, malondialdehyde level and Lee′s heart failure score in the two groups were lower than those before treatment, and those in the combined group were lower than those in the single drug group (all P<0.05). Conclusions hengui capsule combined with Sacubitril/valsartan sodium is effective in the treatment of chronic heart failure, which can effectively improve cardiac function and dyspnea.