2025 年第 8 期 第 20 卷

治疗高尿酸血症的相关药物研究进展

Research progress of related drugs for the treatment of hyperuricemia

作者：马翠马瑜瑾姜宏卫

英文作者：Ma Cui Ma Yujin Jiang Hongwei

单位：河南科技大学第一附属医院内分泌科，洛阳471003

英文单位：Department of Endocrinology The First Affiliated Hospital of Henan University of Science and Technology Luoyang 471003 China

关键词：高尿酸血症；痛风；药物治疗；代谢综合征

英文关键词：Hyperuricemia;Gout;Drugtreatment;Metabolicsyndrome

• 摘要：

• 高尿酸血症是一种常见的代谢性疾病，其主要原因是人体嘌呤代谢紊乱、尿酸排泄减少或产生过多等。长期高尿酸水平不仅可导致痛风发作，还可能对肾脏造成慢性损害，影响患者的生活质量。药物疗法依然是高尿酸血症治疗的首选方法，虽然临床治疗药物能控制部分病症，但仍存在许多不足之处。本文通过对治疗高尿酸血症相关药物研究进展进行综述，并对新型降尿酸药物进行介绍和讨论，希望能为临床用药及新药开发提供参考。

• Hyperuricemia is a common metabolic disease, mainly caused by factors such as purine metabolism disorders in the human body, reduced or excessive excretion of uric acid, etc. Long-term high uric acid levels not only can lead to gout attacks but also may cause chronic damage to the kidney, affecting the quality of life of patients. Drug therapy remains the preferred treatment for hyperuricemia. Although clinical therapeutic drugs can control some conditions, there are still many deficiencies. This article reviews the research progress of drugs related to the treatment of hyperuricemia, and introduces and discusses new uric acid-lowering drugs, hoping to provide references for clinical medication and new drug development.