2025 年第 9 期 第 20 卷

利脑心胶囊联合替罗非班治疗急性心肌梗死的临床研究

Clinical study of Linaoxin capsule combined with tirofiban in the treatment of acute myocardial infarction

作者：张金梁王立涛高昭高鹏

英文作者：Zhang Jinliang Wang Litao Gao Zhao Gao Peng

单位：青岛大学附属医院急诊医学科，青岛266000

英文单位：Department of Emergency Medicine the Affiliated Hospital of Qingdao University Qingdao 266000 China

关键词：急性心肌梗死；替罗非班；利脑心胶囊；心功能；氧化应激；血管内皮功能

英文关键词：Acutemyocardialinfarction;Tirofiban;Linaoxincapsule;Cardiacfunction;Oxidativestress;Vascularendothelialfunction

• 摘要：

• 目的 探讨利脑心胶囊联合替罗非班治疗急性心肌梗死的临床效果。方法 选取2023年9月至2024年9月青岛大学附属医院收治的118例急性心肌梗死患者，以信封抽签法分为观察组和对照组，各59例。对照组以替罗非班治疗，观察组在对照组的基础上联合利脑心胶囊治疗。2组患者均治疗7 d后评估效果。评估2组临床疗效、心功能、心肌损伤标志物、氧化应激、血管内皮功能和不良反应发生情况。结果 观察组总有效率高于对照组［91.5%（54/59）比76.3%（45/59）］（P＜0.05）。治疗后，观察组心功能指标左心室射血分数、每搏输出量、心输出量、心脏指数均高于对照组，心肌损伤标志物血清肌酸激酶同工酶、心肌肌钙蛋白I、肌红蛋白水平均低于对照组（P＜0.05）。治疗后，观察组氧化应激指标血清丙二醛、髓过氧化物酶水平均低于对照组，超氧化物歧化酶水平高于对照组（均P＜0.05）。治疗后，观察组血管内皮功能指标一氧化氮、血管内皮生长因子、血管内皮素1均优于对照组(均P＜0.05)。2组不良反应发生率比较差异无统计学意义（P＞0.05）。结论 利脑心胶囊联合替罗非班治疗急性心肌梗死的临床效果显著，可提升患者心功能，降低心肌损伤标志物水平，抑制机体的氧化应激反应，改善患者的血管内皮功能，治疗安全性良好。

• Objective To investigate the clinical effect of Linaoxin capsule combined with tirofiban in the treatment of acute myocardial infarction. Methods A total of 118 patients with acute myocardial infarction admitted to the Affiliated Hospital of Qingdao University from September 2023 to September 2024 were selected. They were divided into the observation group and the control group by envelope lottery method, with 59 cases in each group. The control group was treated with tirofiban, and the observation group was treated with Linaoxin capsule on the basis of the control group. The effects of the two groups were evaluated after 7 d of treatment. The clinical efficacy, cardiac function, myocardial injury markers, oxidative stress, vascular endothelial function and adverse reactions of the two groups were evaluated. Results The total effective rate of the observation group was higher than that of the control group ［91.5%（54/59） vs 76.3%（45/59）］(P＜0.05). After treatment, the cardiac function indexes of left ventricular ejection fraction, stroke volume, cardiac output, and cardiac index in the observation group were higher than those in the control group, and the levels of serum creatine kinase isoenzyme, cardiac troponin I, and myoglobin in the observation group were lower than those in the control group (all P＜0.05). After treatment, the levels of serum malondialdehyde and myeloperoxidase in the observation group were lower than those in the control group, and the level of superoxide dismutase was higher than that in the control group (all P＜0.05). After treatment, the vascular endothelial function indexes of nitric oxide, vascular endothelial growth factor and vascular endothelin-1 in the observation group were better than those in the control group (all P＜0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P＞0.05). Conclusion The clinical effect of Linaoxin capsule combined with tirofiban in the treatment of acute myocardial infarction is significant, which can improve the cardiac function of patients, reduce the level of myocardial injury markers, inhibit the body′s oxidative stress response, improve the vascular endothelial function of patients, and the treatment safety is good.