2025 年第 9 期 第 20 卷

蒙药沙棘五味散对低氧型肺动脉高压患者的临床效果分析

Analysis of the clinical effect of Mongolian medicine Sandthorn Wuwei powder on patients with hypoxic pulmonary hypertension

作者：张宇王婷

英文作者：Zhang Yu Wang Ting

单位：内蒙古自治区人民医院心血管内科，呼和浩特010010

英文单位：Department of Cardiovascular Medicine Inner Mongolia Autonomous Region People′s Hospital Hohhot 010010 China

关键词：低氧型肺动脉高压；蒙药沙棘五味散；中西医结合治疗

英文关键词：Hypoxicpulmonaryhypertension;MongolianmedicineSandthornWuweipowder;IntegratedtraditionalChineseandWesternmedicinetreatment

• 摘要：

• 目的 探讨蒙药沙棘五味散联合常规治疗对低氧型肺动脉高压（HPH）患者的临床效果及安全性。方法 回顾性分析2022年8月至2024年8月内蒙古自治区人民医院心血管内科收治的89例HPH患者，根据患者治疗方法分为对照组（44例）和观察组（45例）。对照组接受氧疗、利尿剂及钙通道阻滞剂等常规治疗，观察组在对照组基础上加用沙棘五味散治疗，2组均治疗6个月。比较2组治疗前后运动耐力、心肺功能、血气指标、炎症因子、氧化应激标志物、影像学、血管内皮功能、生活质量。比较2组临床疗效。结果 治疗后，观察组6 min步行试验距离、第1秒用力呼气容积、第1秒用力呼气容积/用力肺活量比值、峰值呼气流速、动脉血氧分压、超氧化物歧化酶、一氧化氮代谢产物、右心室射血分数水平均显著高于对照组，Borg评分、肺动脉收缩压、动脉血二氧化碳分压、血红蛋白、白细胞介素6、肿瘤坏死因子α、8-异前列腺素F2α、丙二醛、右心室舒张末期容积、内皮素1、肺高血压特异性量表评分和蒙医证候积分均显著低于对照组（均P＜0.05）。观察组临床治疗总有效率显著高于对照组［80.0%（36/45）比61.4%（27/44）］（P=0.008）。结论 沙棘五味散联合常规治疗可显著改善HPH患者肺血流动力学、运动耐力及生活质量，其机制可能通过抗炎、抗氧化、调节血管内皮功能及抑制肺血管重塑实现，安全性良好。

• Objective To investigate the clinical effect and safety of Mongolian medicine Sandthorn Wuwei powder combined with conventional treatment on patients with hypoxic pulmonary hypertension (HPH). Methods A total of 89 patients with HPH admitted to the Department of Cardiovascular Medicine, Inner Mongolia Autonomous Region People′s Hospital from August 2022 to August 2024 were retrospectively analyzed. According to the treatment method, the patients were divided into the control group (44 cases) and the observation group (45 cases). The control group received conventional treatment such as oxygen therapy, diuretics, and calcium channel blockers, and the observation group was treated with Sandthorn Wuwei powder on the basis of the control group. Both groups were treated for 6 months. The exercise endurance, cardiopulmonary function, blood gas indexes, inflammatory factors, oxidative stress markers, imaging, vascular endothelial function, and quality of life were compared between the two groups before and after treatment. The clinical efficacy was compared between the two groups. Results After treatment, 6 min walking distance, forced expiratory volume in one second, forced expiratory volume in one second/forced vital capacity, peak expiratory flow, arterial oxygen partial pressure, superoxide dismutase, nitric oxide metabolites, and right ventricular ejection fraction levels in the observation group were significantly longer/higher than those in the control group; Borg score, pulmonary artery systolic pressure, arterial partial pressure of carbon dioxide, hemoglobin, interleukin-6, tumor necrosis factor α, 8-isoprostan-F2α, malondialdehyde, right ventricular end diastolic volume, endothelin-1, pulmonary hypertension specific scale score, and Mongolian medicine syndrome score were significantly lower than those in the control group (all P＜0.05). The total effective rate of the observation group was significantly higher than that of the control group ［80.0%(36/45) vs 61.4%(27/44)］(P=0.008). Conclusions andthorn Wuwei powder combined with conventional treatment can significantly improve pulmonary hemodynamics, exercise endurance and quality of life in patients with HPH, and its mechanism may be achieved by anti-inflammation, anti-oxidation, regulation of vascular endothelial function and inhibition of pulmonary vascular remodeling, with good safety.