2025 年第 9 期 第 20 卷

肾康注射液联合左西孟旦对冠状动脉旁路移植术后早期急性肾损伤患者心肾功能和炎症指标的影响

The effect of Shenkang injection combined with levosimendan on cardiac and renal function and inflammatory indexes in patients with early acute kidney injury after coronary artery bypass grafting

作者：王欢1屈晓宇1蒋涛2

英文作者：Wang Huan1 Qu Xiaoyu1 Jiang Tao2

单位：1中国人民解放军北部战区总医院心外科，沈阳110000；2中国人民解放军北部战区空军医院心血管内科，沈阳110000

英文单位：1Department of Cardiac Surgery General Hospital of Northern Theater Command of the Chinese People′s Liberation Army Shenyang 110000 China; 2Department of Cardiovascular Medicine Air Force Hospital of Northern Theater Command of the Chinese People′s Liberation Army Shenyang 110000 China

关键词：急性肾损伤；冠状动脉旁路移植术；肾康注射液；左西孟旦；心功能；肾功能；炎症反应

英文关键词：Acutekidneyinjury;Coronaryarterybypassgrafting;Shenkanginjection;Levosimendan; Cardiacfunction;Renalfunction;Inflammatoryresponse

• 摘要：

• 目的 探讨冠状动脉旁路移植术（CABG）后早期急性肾损伤（AKI）患者应用肾康注射液联合左西孟旦治疗的临床效果。方法 选取2023年2月至2024年9月中国人民解放军北部战区总医院收治的110例CABG后早期AKI患者。采用随机数字表法分为对照组和观察组，各55例。对照组在常规综合治疗基础上予以左西孟旦注射液治疗，观察组在对照组基础上加用肾康注射液治疗，比较2组临床疗效、心功能、肾功能、炎症指标及不良反应。结果 观察组治疗总有效率高于对照组［94.5%（52/55）比80.0%（44/55）］（P=0.022）。2组治疗后左心室短轴缩短率、左心室射血分数、肾小球滤过率均高于治疗前且观察组均高于对照组，24 h尿蛋白、尿微量蛋白、血肌酐、血尿素氮、白细胞介素6（IL-6）、IL-8、IL-18水平均低于治疗前且观察组均低于对照组（均P＜0.05）。2组不良反应总发生率比较差异无统计学意义（P=1.000）。结论 CABG后早期AKI患者应用肾康注射液联合左西孟旦治疗效果满意，能够改善患者的心肾功能，有效抑制体内的炎症反应，临床应用安全可靠。

• Objective To investigate the clinical effect of Shenkang injection combined with levosimendan on patients with early acute kidney injury (AKI) after coronary artery bypass grafting (CABG). Methods A total of 110 patients with early AKI after CABG admitted to General Hospital of Northern Theater Command of Chinese People′s Liberation Army from February 2023 to September 2024 were selected. According to the random number table method, they were divided into control group and observation group, with 55 cases in each group. The control group was treated with levosimendan injection on the basis of conventional comprehensive treatment, and the observation group was treated with Shenkang injection on the basis of the control group. The clinical efficacy, cardiac function, renal function, inflammatory indicators and adverse reactions were compared between the two groups. Results The total effective rate of the observation group was higher than that of the control group ［94.5%(52/55) vs 80.0%(44/55)］(P=0.022). After treatment, the left ventricular fractional shortening, left ventricular ejection fraction, and glomerular filtration rate of the two groups were higher than those before treatment, and those of the observation group were higher than those of the control group. The levels of 24 h urine protein, urine microprotein, serum creatinine, blood urea nitrogen, interleukin-6 (IL-6), IL-8, and IL-18 of the two groups were lower than those before treatment, and those of the observation group were lower than those of the control group (all P<0.05). There was no significant difference in the total incidence of adverse reactions between the two groups (P=1.000). Conclusions henkang injection combined with levosimendan in the treatment of patients with early AKI after CABG is effective, which can improve the heart and kidney function of patients, effectively inhibit the inflammatory response in the body, and is safe and reliable in clinical application.