2025 年第 9 期 第 20 卷

补肺活血胶囊联合岩盐气溶胶疗法治疗尘肺的临床效果

The clinical effect of BufeiHuoxue capsule combined with rock salt aerosol therapy in the treatment of pneumoconiosis

作者：刘魏潘健窦红张毅阿明古丽张祎马艳艳

英文作者：Liu Wei Pan Jian Dou Hong Zhang Yi Amingguli Zhang Yi Ma Yanyan

单位：新疆维吾尔自治区第三人民医院呼吸与危重症医学科，乌鲁木齐841003

英文单位：Department of Respiratory and Critical Care Medicine Third People′s Hospital of Xinjiang Uygur Autonomous Region Urumqi 841003 China

关键词：尘肺；补肺活血胶囊；中医；岩盐气溶胶；肺功能

英文关键词：Pneumoconiosis;BufeiHuoxuecapsule;TraditionalChinesemedicine;Rocksaltaerosol; Lungfunction

• 摘要：

• 目的 探讨补肺活血胶囊联合岩盐气溶胶疗法对尘肺治疗的效果及对患者运动耐力、肺功能等的影响。方法 选取新疆维吾尔自治区第三人民医院2021年2月至2023年6月收治的87例尘肺患者，采用随机数字表法分为观察组（44例）和对照组（43例）。对照组在基础治疗基础上给予岩盐气溶胶疗法；观察组在对照组基础上给予补肺活血胶囊口服治疗。比较2组总有效率、呼吸功能、肺功能指标、血清生化指标、运动耐力及安全性。结果 观察组总有效率高于对照组［93.2%（41/44）比76.7%（33/43）］（P＜0.05）。治疗后，观察组与对照组圣乔治呼吸问卷评分均低于治疗前，且观察组低于对照组［（52±6）分比（60±8）分］（P＜0.001）；2组第1秒用力呼气容积、用力肺活量水平均高于治疗前，且观察组均高于对照组（均P<0.05）。治疗后，2组白细胞介素8水平均低于治疗前，且观察组低于对照组；2组γ-干扰素水平均高于治疗前，且观察组高于对照组（均P<0.05）。治疗后，观察组与对照组6 min步行试验距离均长于治疗前，且观察组长于对照组［（366±39）m比（331±35）m］（P＜0.001）。2组不良反应发生率比较差异无统计学意义（P＞0.05）。结论 尘肺患者接受补肺活血胶囊+岩盐气溶胶疗法联合干预，可有效提升机体肺功能，增强运动耐力。

• Objective To investigate the effect of BufeiHuoxue capsule combined with rock salt aerosol therapy on pneumoconiosis, and its influence on exercise endurance and lung function of patients. Methods A total of 87 pneumoconiosis patients admitted to the Third People′s Hospital of Xinjiang Uygur Autonomous Region from February 2021 to June 2023 were selected. They were divided into observation group (44 cases) and control group (43 cases) by random number table method. The control group was given rock salt aerosol therapy on the basis of basic treatment. The observation group was treated with BufeiHuoxue capsule on the basis of the control group. The total effective rate, respiratory function, lung function index, serum biochemical index, exercise tolerance and safety were compared between the two groups. Results The total effective rate of the observation group was higher than that of the control group ［93.2%(41/44) vs 76.7%(33/43)］(P<0.05). After treatment, the St. George′s Respiratory Questionnaire scores of the observation group and the control group were lower than those before treatment, and that of the observation group was lower than that of the control group ［(52±6) vs (60±8)］(P<0.001). The forced expiratory volume and forced vital capacity levels in the first second of both groups were higher than before treatment, and those in the observation group were higher than those in the control group (all P<0.05). After treatment, the levels of interleukin-8 in the two groups were lower than those before treatment, and that in the observation group was lower than that in the control group; the levels of γ-interferon in the two groups were higher than those before treatment, and that in the observation group was higher than that in the control group(all P<0.05). After treatment, the 6 min walk test distances of the observation group and the control group were longer than those before treatment, and the 6minwalk test distance of the observation group was longer than that of the control group ［(366±39)m vs (331±35)m］(P<0.001). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion BufeiHuoxue capsule combined with rock salt aerosol therapy can effectively improve the lung function and exercise endurance of pneumoconiosis patients.