2025 年第 9 期 第 20 卷

曲美他嗪改善心血管疾病内皮功能障碍作用的研究进展

Research progress on the role of trimetazidine in improving endothelial dysfunction in cardiovascular diseases

作者：张嘉祺王茜婷陈夏欢刘梅林

英文作者：Zhang Jiaqi Wang Xiting Chen Xiahuan Liu Meilin

单位：北京大学第一医院老年病内科，北京100034

英文单位：Department of Geriatrics Peking University First Hospital Beijing 100034 China

关键词：心血管疾病；曲美他嗪；内皮功能障碍；能量代谢；氧化应激

英文关键词：Cardiovasculardiseases;Trimetazidine;Endothelialdysfunction;Energymetabolism;Oxidativestress

• 摘要：

• 心血管疾病是威胁人类健康的主要原因之一，其核心病理生理学特征为内皮功能障碍，表现为血管舒张能力下降、血流动力学异常以及动脉粥样硬化进展加速等。曲美他嗪通过优化能量代谢、改善血流动力学、减轻氧化应激、抑制炎症反应、调节血管生成等途径，有效改善内皮功能障碍，广泛应用于多种心血管疾病的治疗。本文综述了曲美他嗪的作用机制及其在改善心血管疾病相关内皮功能障碍方面的最新研究进展，为临床更好地应用曲美他嗪提供新的策略和依据。

• Cardiovascular disease is a major threat to human health. Its core pathophysiological features are endothelial dysfunction, which is manifested as decreased vasodilation ability, hemodynamic abnormalities, and accelerated progression of atherosclerosis.Trimetazidine can effectively improve endothelial dysfunction by optimizing energy metabolism, improving hemodynamics, reducing oxidative stress, inhibiting inflammatory response, and regulating angiogenesis, and is widely used in the treatment of a variety of cardiovascular diseases. This article reviews the mechanism of trimetazidine and its latest research progress in improving endothelial dysfunction related to cardiovascular disease, so as to provide new strategies and evidence for better clinical application of trimetazidine.