2025 年第 6 期 第 20 卷

普罗布考联合阿托伐他汀治疗急性脑梗死的效果及对患者血脂的影响

The effect of probucol combined with atorvastatin in the treatment of acute cerebral infarction and its effect on patients′ blood lipids

作者：鲁秀秀杨健军

英文作者：Lu Xiuxiu Yang Jianjun

单位：山东省立第三医院全科医学科，济南250000

英文单位：Department of General Medicine Shandong Provincial Third Hospital Jinan 250000 China

关键词：急性脑梗死；普罗布考；阿托伐他汀；血脂水平；动脉粥样硬化斑块；炎症因子

英文关键词：Acutecerebralinfarction;Probucol;Atorvastatin;Bloodlipidlevel;Atheroscleroticplaque;Inflammatoryfactor

• 摘要：

• 目的 探讨普罗布考联合阿托伐他汀治疗急性脑梗死的效果及对患者血脂的影响。方法 选取2022年1月至2024年1月山东省立第三医院收治的96例急性脑梗死患者，按照随机数字表法分为观察组和对照组，各48例。对照组给予以阿托伐他汀为主的常规治疗，观察组在对照组基础上增加普罗布考片治疗。所有患者治疗12周。比较2组临床疗效、血脂指标、颈动脉斑块超声参数、血清炎症因子水平和治疗安全性。结果 观察组总有效率高于对照组［91.7%(44/48)比72.9%(35/48)］，差异有统计学意义（P=0.016）。治疗后，2组血脂指标均优于治疗前，且观察组血脂指标水平均优于对照组（均P＜0.05）。治疗后，观察组颈动脉内膜中层厚度、血管阻力指数均小于对照组，收缩期最大流速、舒张末期最大流速均高于对照组（均P＜0.05）。治疗后，观察组炎症因子基质金属蛋白酶2、核苷酸结合寡聚化结构域样受体蛋白3、白细胞介素1β水平均低于对照组（P＜0.05）。2组不良反应发生率比较差异无统计学意义（P＞0.05）。结论 普罗布考联合阿托伐他汀治疗急性脑梗死有良好效果，可改善患者血脂水平，稳定颈动脉斑块，改善颈动脉血流速度，降低血清炎症因子水平，治疗安全性良好。

• Objective To explore the effect of probucol combined with atorvastatin in the treatment of acute cerebral infarction and its effect on patients′ blood lipids. Methods A total of 96 patients with acute cerebral infarction admitted to the Shandong Provincial Third Hospital from January 2022 to January 2024 were selected. They were divided into observation group and control group according to the random number table method, with 48 cases in each group.The control group was given conventional treatment based on atorvastatin, and the observation group was treated with probucol tablets on the basis of the control group. All patients were treated for 12 weeks. The clinical efficacy, blood lipid indexes, ultrasound parameters of carotid plaque, inflammatory factors, and treatment safety were compared between the two groups. Results The total effective rate of the observation group was higher than that of the control group ［91.7%(44/48) vs 72.9%(35/48)］(P=0.016). After treatment, the blood lipid indexes of the two groups were better than those before treatment, and the blood lipid indexes of the observation group were better than those of the control group (all P＜0.05). After treatment, the carotid intima-media thickness and vascular resistance index of the observation group were less than those of the control group, and the maximum systolic velocity and the maximum end-diastolic velocity were higher than those of the control group (all P＜0.05). After treatment, the levels of inflammatory factors matrix metalloproteinase-2, nucleotide-binding oligomerization domain-like receptor protein 3 and interleukin-1β in the observation group were lower than those in the control group (all P＜0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P＞0.05). Conclusion Probucol combined with atorvastatin has a good application effect on acute cerebral infarction, which can improve the blood lipid level of patients, stabilize the carotid plaque of patients, improve the carotid blood flow velocity, reduce the level of inflammatory factors, and has good treatment safety.