2025 年第 6 期 第 20 卷

加巴喷丁对人类免疫缺陷病毒感染患者术前焦虑及插管反应的影响

Effects of gabapentin on preoperative anxiety and intubation response in patients with human immunodeficiency virus infection

作者：董萍牛少宁赵丽琴赵娜娜刘欣娜程灏

英文作者：Dong Ping Niu Shaoning Zhao Liqin Zhao Nana Liu Xinna Cheng Hao

单位：首都医科大学附属北京地坛医院麻醉科，北京100015

英文单位：Department of Anesthesiology Beijing Ditan Hospital Capital Medical University Beijing 100015 China

关键词：人类免疫缺陷病毒；加巴喷丁；术前焦虑；插管反应

英文关键词：Humanimmunodeficiencyvirus;Gabapentin;Preoperativeanxiety;Intubationresponse

• 摘要：

• 目的 探讨加巴喷丁对人类免疫缺陷病毒（HIV）感染患者术前焦虑及插管反应的影响。方法 选择2023年5月至2024年11月于首都医科大学附属北京地坛医院择期全身麻醉下行非心脏手术治疗的HIV感染患者68例，按照随机数字表法分为观察组和对照组，各34例。对照组手术前晚给予安慰剂口服；观察组手术前晚给予加巴喷丁胶囊口服。比较2组术前、入手术室即刻疼痛视觉模拟量表（VAS）评分、状态-特质焦虑问卷（STAI-S）评分；比较2组麻醉诱导前、气管插管时及插管后1、3、5、10 min的心率、平均动脉压（MAP）。记录2组不良反应发生情况。结果 2组术前、入手术室即刻、麻醉恢复室时VAS评分比较差异均无统计学意义（均P＞0.05）。观察组入手术室即刻STAI-S评分低于术前，且低于对照组同时点［（39±5）分比（43±5）分］（均P＜0.05）。观察组气管插管时及插管后1、3、10 min 心率及MAP水平均低于对照组，差异均有统计学意义（均P＜0.05）。2组术后不良反应发生率比较差异均无统计学意义（均P＞0.05）。结论 加巴喷丁可降低HIV感染患者术前焦虑及插管反应，且并不延长麻醉恢复室停留时间。

• Objective To investigate the effect of gabapentin on preoperative anxiety and intubation reaction in patients with human immunodeficiency virus (HIV) infection. Methods A total of 68 HIV-infected patients who underwent elective general anesthesia and non-cardiac surgical treatment at Beijing Ditan Hospital, Capital Medical University from May 2023 to November 2024 were selected. According to the random number table method, they were divided into the observation group and the control group, with 34 cases in each group. The control group received placebo orally the night before surgery, and the observation group was given gabapentin capsules orally the night before surgery. The visual analogue scale (VAS) score and state-trait anxiety questionnaire (STAI-S) score were compared between the two groups at the preoperative and immediately after entering the operating room. The heart rate and mean arterial pressure (MAP) were compared between the two groups before anesthesia induction, during tracheal intubation and 1, 3, 5, 10 min after intubation. The occurrence of adverse reactions in the two groups was recorded. Results There was no significant difference in VAS scores between the two groups before operation, immediately into the operating room, and at the time of anesthesia recovery room (all P>0.05). The STAI-S score in the observation group was lower than that before operation and that in the control group at the same time point ［(39±5) vs (43±5)］(all P<0.05). The heart rate and MAP levels of the observation group were lower than those of the control group at the time of tracheal intubation and 1, 3, 10 min after intubation (all P<0.05). There was no significant difference in the incidence of postoperative adverse reactions between the two groups (all P>0.05). Conclusions Gabapentin can reduce preoperative anxiety and intubation reactions in HIV-infected patients, without prolonging the duration of stay in the anesthesia recovery room.