2026 年第 4 期 第 21 卷

细胞衰老在顺铂所致急性肾脏损伤与肾脏纤维化中的作用机制研究进展

Research progress on the mechanism of cellular senescence in cisplatin-induced acute kidney injury and renal fibrosis

作者：梁彧欣1林兰彦2周悦2王豫伟2孔繁兴2徐煌3李素华1

英文作者：Liang Yuxin1 Lin Lanyan2 Zhou Yue2 Wang Yuwei2 Kong Fanxing2 Xu Huang3 Li Suhua1

单位：1新疆医科大学第一附属医院（新疆医科大学第一临床医学院）肾脏疾病中心新疆维吾尔自治区肾脏病研究所新疆肾脏替代治疗临床医学研究中心，乌鲁木齐830054；2新疆医科大学临床医学部，乌鲁木齐830017；3新疆医科大学口腔医学院，乌鲁木齐830017

英文单位：1Kidney Disease Center the First Affiliated Hospital of Xinjiang Medical University(the First Clinical Medical College of Xinjiang Medical University) Xinjiang Uygur Autonomous Region Kidney Disease Research Institute Xinjiang Clinical Medical Research Center for Renal Replacement Therapy Urumqi 830054 China; 2Department of Clinical Medicine Xinjiang Medical University Urumqi 830017 China; 3School of Stomatology Xinjiang Medical University Urumqi 830017 China

关键词：急性肾损伤；肾脏纤维化；细胞衰老；顺铂

英文关键词：Acutekidneyinjury;Renalfibrosis;Cellularsenescence;Cisplatin

• 摘要：

• 顺铂是许多癌症治疗的一线化疗药物，但因其肾脏毒性在临床应用中受到一些限制。近年研究发现，细胞衰老在顺铂所致急性肾损伤进程中发挥关键作用。细胞衰老表现为不可逆的细胞周期停滞，衰老细胞可以通过分泌多种炎性因子及促纤维化因子，构成衰老相关分泌表型，引起周围环境改变，进而驱动急性肾损伤向慢性肾脏病进展。因此靶向清除衰老细胞可能成为顺铂治疗期间肾脏保护的潜在治疗靶点，但其具体机制并不明确。本综述旨在阐述细胞衰老在顺铂诱导急性肾损伤及肾脏纤维化中的作用，期望能为防治顺铂毒副作用提供新的理论依据。

• Cisplatin is a first-line chemotherapeutic agent for the treatment of various cancers, but its clinical application is limited due to its nephrotoxicity. Recent studies have found that cellular senescence plays a key role in the progression of cisplatin-induced acute kidney injury (AKI). Cellular senescence is characterized by irreversible cell cycle arrest, and senescent cells can form a senescence-associated secretory phenotype by secreting a variety of inflammatory and profibrotic factors, which alters the surrounding microenvironment and further drives the progression of AKI to chronic kidney disease. Therefore, targeted clearance of senescent cells may serve as a potential therapeutic target for renal protection during cisplatin treatment, while its specific mechanism remains unclear. This review aims to elaborate on the role of cellular senescence in cisplatin-induced AKI and renal fibrosis, hoping to provide a new theoretical basis for the prevention and treatment of cisplatin-induced toxic and side effects.