2025 年第 12 期 第 20 卷

阿立哌唑联合加兰他敏对老年痴呆患者精神行为症状及认知功能的影响

The effect of aripiprazole combined with galantamine on psychological and behavioral symptoms and cognitive function in patients with senile dementia

作者：朱红郭忠伟周颖璨

英文作者：Zhu Hong Guo Zhongwei Zhou Yingcan

单位：浙江省立同德医院老年三科，杭州310000

英文单位：Third Department of Geriatrics Tongde Hospital of Zhejiang Province Hangzhou 310000 China

关键词：老年痴呆；阿立哌唑；加兰他敏；认知功能

英文关键词：Seniledementia;Aripiprazole;Galanthamine;Cognitivefunction

• 摘要：

• 目的 分析阿立哌唑联合加兰他敏治疗伴有精神行为症状的老年痴呆患者的临床效果。方法 选取浙江省立同德医院2024年5月至2025年3月收治的伴有精神行为症状的老年痴呆患者106例。按区组随机法分为观察组和对照组，各53例。对照组在常规治疗基础上口服氢溴酸加兰他敏片治疗，观察组在对照组基础上联合阿立哌唑片治疗，2组均持续治疗3个月。比较2组患者治疗前后精神行为症状和认知功能相关评分、神经因子水平以及治疗期间不良反应发生情况。结果 治疗后，2组患者痴呆病理行为评定量表、阿尔茨海默病评估量表-认知部分、临床痴呆评定量表评分均低于治疗前且观察组均低于对照组，差异均有统计学意义（均P＜0.05）。治疗后，2组患者脑源性神经营养因子水平均高于治疗前且观察组高于对照组［（32±6）μg/L比(28±5)μg/L］，视锥蛋白样蛋白1、神经元特异烯醇化酶水平均低于治疗前且观察组均低于对照组，差异均有统计学意义（均P＜0.05）。2组不良反应发生率比较差异无统计学意义（P＞0.05）。结论 阿立哌唑联合加兰他敏治疗伴有精神行为症状的老年痴呆患者效果显著，能够改善患者精神行为症状、认知功能及神经因子水平，且不会增加不良反应发生风险，安全性良好。

• Objective To analyze the clinical effect of aripiprazole combined with galantamine in the treatment of senile dementia patients with behavioral and psychological symptoms. Methods A total of 106 senile dementia patients with behavioral and psychological symptoms admitted to Tongde Hospital of Zhejiang Province from May 2024 to March 2025 were selected. According to the block random method, they were divided into the observation group and the control group, with 53 cases in each group. The control group was treated with oral galantamine hydrobromide tablets on the basis of conventional treatment, and the observation group was treated with aripiprazole tablets on the basis of the control group. Both groups were treated for 3 months.Before and after treatment, the scores of psychological and behavioral symptoms and cognitive function, the levels of nerve factors, and the incidence of adverse reactions during treatment were compared between the two groups. Results After treatment, the scores of dementia pathological behavior rating scale, Alzheimer′s disease assessment scale-cognitive part and clinical dementia rating scale in the two groups were lower than those before treatment, and those in the observation group were lower than those in the control group(all P<0.05). After treatment, the levels of brain-derived neurotrophic factor in the two groups were higher than those before treatment, and those in the observation group were higher than those in the control group ［（32±6）μg/L vs (28±5)μg/L］; the levels of visinin-like protein 1 and neuron specific enolase in the two groups were lower than those before treatment, and those in the observation group were lower than those in the control group(all P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05). Conclusion Aripiprazole combined with galantamine is effective in the treatment of senile dementia patients with mental and behavioral symptoms, which can improve the patients′ mental and behavioral symptoms, cognitive function and nerve factors, and does not increase the risk of adverse reactions, with good safety.