2026 年第 7 期 第 21 卷

麝香保心丸联合尼可地尔对冠状动脉慢血流患者血管内皮功能和炎症因子的影响

Effects of Shexiang Baoxin pills combined with nicorandil on vascular endothelial function and inflammatory factors in patients with coronary slow flow

作者：吴月张璟轶李昌张胜利梁荻

英文作者：Wu Yue Zhang Jingyi Li Chang Zhang Shengli Liang Di

单位：江汉大学附属湖北省第三人民医院心血管内科，武汉430000

英文单位：Department of Cardiovascular Medicine the Third People′s Hospital of Hubei Province Jianghan University Wuhan 430000 China

关键词：冠状动脉慢血流；麝香保心丸；尼可地尔；血管内皮功能；炎症

英文关键词：Coronaryslowflow;ShexiangBaoxinpills;Nicorandil;Vascularendothelialfunction;Inflammation

• 摘要：

• 目的 探究麝香保心丸联合尼可地尔对冠状动脉慢血流（CSF）患者的治疗效果及对血管内皮功能及炎症因子水平的影响。方法 选择2023年6月至2024年12月湖北省第三人民医院心血管内科收治的CSF患者100例作为研究对象。采用随机数字表法将患者分为对照组和观察组，每组50例。对照组给予常规基础药物和尼可地尔片治疗；观察组在对照组基础上给予麝香保心丸治疗，2组均治疗6个月。比较2组患者的临床疗效、冠状动脉主要分支的校正TIMI帧数（CTFC）、血清血管内皮功能指标、血清炎症因子指标、不良反应情况。结果 观察组总有效率高于对照组［96.0%（48/50）比84.0%（42/50）］，差异有统计学意义（χ2=4.000，P=0.046）。治疗后，2组冠状动脉主要分支的CTFC均低于治疗前，且观察组均显著低于对照组（均P<0.05）。治疗后，2组血清内皮素1水平均低于治疗前，且观察组低于对照组；一氧化氮水平均高于治疗前，且观察组高于对照组（均P<0.05）。治疗后，2组患者血清炎症因子指标均低于治疗前，且观察组均低于对照组（均P<0.05）。2组不良反应发生率比较差异无统计学意义（χ2=0.122，P=0.727）。结论 麝香保心丸联合尼可地尔治疗CSF的效果明确，可调节冠状动脉主要分支的血流速度，改善血管内皮功能，抑制炎症反应，安全性高。

• Objective To investigate the therapeutic effect of Shexiang Baoxin Pills combined with nicorandil on patients with coronary slow flow (CSF) and its influence on vascular endothelial function and levels of inflammatory factors. Methods A total of 100 CSF patients admitted to the Department of Cardiovascular Medicine, the Third People′s Hospital of Hubei Province from June 2023 to December 2024 were selected as subjects. Patients were divided into control group and observation group by random number table method, with 50 cases in each group. The control group was treated with conventional basic drugs and nicorandil tablets; the observation group was additionally given Shexiang Baoxin pills on the basis of the control group. Both groups were treated for 6 months. Clinical efficacy, corrected TIMI frame count (CTFC) of main coronary branches, serum vascular endothelial function indexes, serum inflammatory factor indexes and adverse reactions were compared between the two groups. Results The total effective rate of the observation group was higher than that of the control group ［96.0%(48/50) vs 84.0%(42/50)］(χ2=4.000, P=0.046). After treatment, the CTFC of main coronary branches in both groups was lower than that before treatment, and those in the observation group were significantly lower than those in the control group (all P<0.05). After treatment, the serum endothelin-1 level in both groups was lower than that before treatment, and that in the observation group was lower than that in the control group; the nitric oxide level was higher than that before treatment, and that in the observation group was higher than that in the control group (all P<0.05). After treatment, serum inflammatory factor indexes in both groups were lower than those before treatment, and those in the observation group were lower than those in the control group (all P<0.05). There was no statistically significant difference in the incidence of adverse reactions between the two groups (χ2=0.122, P=0.727). Conclusion Shexiang Baoxin pills combined with nicorandil has a definite effect in the treatment of CSF, which can regulate blood flow velocity of main coronary branches, improve vascular endothelial function, inhibit inflammatory response, and has high safety.