2026 年第 8 期 第 21 卷

压电材料在颅脑创伤修复中的研究进展

Research progress of piezoelectric materials in craniocerebral trauma repair

作者：崔松梅1石学颖2卞子薇2孙洪涛2高若妍2

英文作者：Cui Songmei1 Shi Xueying2 Bian Ziwei2 Sun Hongtao2 Gao Ruoyan2

单位：1中国人民武装警察部队特色医学中心急诊医学科，天津300162；2中国人民武装警察部队特色医学中心神经创伤及修复研究所，天津300162

英文单位：1Department of Emergency Medicine Characteristic Medical Center of Chinese People′s Armed Police Force Tianjin 300162 China; 2Institute of Neurotrauma and Repair Characteristic Medical Center of Chinese People′s Armed Police Force Tianjin 300162 China

关键词：创伤性脑损伤；压电材料；脑损伤修复；神经再生；神经组织工程

英文关键词：Traumaticbraininjury;Piezoelectricmaterials;Braininjuryrepair;Nerveregeneration; Neuraltissueengineering

• 摘要：

• 颅脑创伤作为一种严重威胁全球公共健康的神经系统疾病，常导致持久的神经功能障碍和沉重的社会经济负担。近年来，压电材料凭借其将机械刺激转化为电信号的独特性能，在脑损伤修复领域引起广泛关注。本文系统总结了脑损伤的病理生理机制及压电材料的分类和生物电特性，重点阐述了压电生物材料在促进神经细胞生长、分化及修复中的应用进展，探讨了多功能压电材料在神经组织工程中的潜力与存在的技术挑战。旨在为压电材料在脑损伤修复中的临床应用提供理论依据，推动其临床转化与神经再生治疗的进展。

• As a neurological disease that seriously threatens global public health, craniocerebral trauma often leads to persistent neurological dysfunction and heavy socio-economic burden. In recent years, piezoelectric materials have attracted extensive attention in the field of brain injury repair by virtue of their unique property of converting mechanical stimulation into electrical signals. This paper systematically summarizes the pathophysiological mechanism of brain injury, the classification and bioelectrical properties of piezoelectric materials, focuses on the application progress of piezoelectric biomaterials in promoting the growth, differentiation and repair of nerve cells, and discusses the potential and existing technical challenges of multifunctional piezoelectric materials in neural tissue engineering. It aims to provide a theoretical basis for the clinical application of piezoelectric materials in brain injury repair and promote the development of their clinical transformation and neural regeneration therapy.