2026 年第 9 期 第 21 卷

脊髓类器官在脊髓损伤修复中的研究前沿与思考

Research frontiers and reflections on spinal cord organoids in spinal cord injury repair

作者：王致远1吴为栋1,2徐海亮1,2刘宥君1,2李辉1,2朱雷2

英文作者：Wang Zhiyuan1 Wu Weidong12 Xu Hailiang12 Liu Youjun12 Li Hui12 Zhu Lei2

单位：1西安交通大学，西安710000；2西安交通大学附属红会医院脊柱病院，西安710000

英文单位：1Xi′an Jiaotong University Xi′an 710000 China; 2Spine Hospital Honghui Hospital Xi′an Jiaotong University Xi′an 710000 China

关键词：脊髓损伤；脊髓类器官；神经修复

英文关键词：Spinalcordinjury;Spinalcordorganoids;Nerverepair

• 摘要：

• 近年来类器官技术受到了空前广泛的关注。它凭借能够构建出更接近人体生理状态的复杂微环境，在生物医学的多个领域展现出巨大的应用价值。脊髓类器官的成功构建，标志着类器官技术向模拟人体最精细、最复杂的指挥中枢迈出了至关重要的一步。本文通过回顾近十年脊髓类器官在脊髓损伤修复领域中的相关研究，回顾了脊髓类器官的发展与由来，深入探讨了脊髓类器官前沿构建方案的研究进展与其在脊髓损伤修复领域的重要应用，并对脊髓类器官研发中存在的重要问题和未来的发展方案进行了深度思考。

• Organoid technology has attracted unprecedented extensive attention in recent years. It can construct a complex microenvironment closer to the physiological state of human body, showing great application value in multiple biomedical fields. The successful generation of spinal cord organoids marks a crucial step of organoid technology toward simulating the most sophisticated and complex command center of human body. By reviewing relevant studies on spinal cord organoids in the field of spinal cord injury repair over the past decade, this article summarizes the origin and development of spinal cord organoids, elaborates on the research progress of cutting-edge construction protocols and their important applications in spinal cord injury repair, and discusses the major challenges and future development strategies in the research and development of spinal cord organoids.