2018 年第 4 期 第 13 卷

利拉鲁肽治疗2型糖尿病合并多囊卵巢综合征的临床效果观察

Clinical effect of liraglutide on type 2 diabetes mellitus complicated with polycystic ovary syndrome

作者：李秋云刘星李昊轩杨春伟张卫欢王婷婷郭智慧周艳茹

英文作者：

单位：063000河北省唐山市，开滦总医院内分泌科（李秋云、刘星、杨春伟、张卫欢、王婷婷、郭智慧、周艳茹）；510515广州，南方医科大学临床医学系(李昊轩)

英文单位：

关键词：糖尿病，2型；利拉鲁肽；多囊卵巢综合征

英文关键词：

• 摘要：

• 目的    探讨利拉鲁肽对2型糖尿病合并多囊卵巢综合征患者的临床疗效。方法    选取2015年 1月至2016年12月于开滦总医院就诊的2型糖尿病合并多囊卵巢综合征患者60例，应用随机数字表分为2组，各30例。对照组采取饮食运动干预方法，观察组在对照组基础上联合利拉鲁肽治疗，24周为1个疗程,比较2组患者治疗前后的腰围、体重指数、空腹血糖、糖化血红蛋白和血脂,并行彩色多普勒超声检查测量成熟卵泡直径。结果    治疗前2组患者的年龄、腰围、体重指数、空腹血糖、糖化血红蛋白和血脂以及成熟卵泡直径比较差异均无统计学意义（均P>0.05）。治疗后，对照组空腹血糖、糖化血红蛋白、体重指数、腰围均低于治疗前，成熟卵泡直径大于治疗前（均P＜0.05）；观察组低密度脂蛋白胆固醇、三酰甘油、总胆固醇、空腹血糖、糖化血红蛋白、体重指数、腰围均低于治疗前,高密度脂蛋白胆固醇高于、成熟卵泡直径大于治疗前（均P＜0.05）；且观察组治疗后总胆固醇、空腹血糖、糖化血红蛋白均低于对照组［(5.4±0.8)mmol/L比(5.8±0.8)mmol/L、(6.6±0.5)mmol/L比(7.7±0.8)mmol/L、(5.2±0.4)%比(5.8±1.0)%］,高密度脂蛋白胆固醇高于、成熟卵泡直径大于对照组［(1.43±0.22)mmol/L比(1.25±0.27)mmol/L、(1.10±0.10)cm比(0.83±0.11)cm］，差异均有统计学意义（均P＜0.05）。结论    利拉鲁肽治疗2型糖尿病合并多囊卵巢综合征可明显降低患者的空腹血糖、糖化血红蛋白和总胆固醇，并促进卵泡发育。

• Objective    To explore the clinical effect of liraglutide on type 2 diabetes mellitus complicated with polycystic ovary syndrome. Methods    Sixty type 2 diabetic patients with polycystic ovary syndrome who visited Kailuan General Hospital from January 2015 to December 2016 were randomly divided into control group and observation group, with 30 cases in each group. The control group had diet and exercise intervention; the observation group was treated by liraglutide for 24 weeks. Waist circumference, body mass index, fasting blood glucose, glycosylated hemoglobin and blood lipid were analyzed before and after treatment. Diameter of mature follicle was measured by color Doppler ultrasound. Results   There were no significant differences of age, waist circumference, body mass index, fasting blood glucose, glycosylated hemoglobin, blood lipid and mature follicle diameter between groups before treatment（P>0.05）. After treatment, fasting blood glucose, glycosylated hemoglobin, body mass index, waist circumference in control group were significantly lower and mature follicle diameter was significantly higher than those before treatment（P＜0.05）; low-density lipoprotein cholesterol, triacylglycerol, total cholesterol, fasting blood glucose, glycosylated hemoglobin, body mass index, waist circumference in observation group were significantly lower and high-density lipoprotein cholesterol, mature follicle diameter were significantly higher than those before treatment（P＜0.05）. Total cholesterol, fasting blood glucose and glycosylated hemoglobin after treatment in observation group were significantly lower than those in control group［(5.4±0.8)mmol/L vs (5.8±0.8)mmol/L, (6.6±0.5)mmol/L vs (7.7±0.8)mmol/L, (5.2±0.4)% vs (5.8±1.0)%］; high-density lipoprotein cholesterol and mature follicle diameter after treatment in observation group were significantly higher than those in control group［(1.43±0.22)mmol/L vs (1.25±0.27)mmol/L, (1.10±0.10)cm vs (0.83±0.11)cm］（P＜0.05）. Conclusion    Lirolipotine treating type 2 diabetes complicated with polycystic ovary syndrome can effectively reduce blood glucose, glycosylated hemoglobin, total cholesterol and promote follicular development.