2018 年第 5 期 第 13 卷

抗肿瘤药物与输液包装材料相容性的研究进展

Research progress of compatibility between antitumor drugs and infusion packaging materials

作者：王睿晴张艳华

英文作者：

单位：100142北京市肿瘤防治研究所北京大学肿瘤医院药剂科恶性肿瘤发病机制及转化研究教育部重点实验室（王睿晴现就读于北京大学医学部药学院药事管理与临床药学系）

英文单位：

关键词：抗肿瘤药物；输液包装材料；相容性；聚氯乙烯；聚烯烃热塑弹性体

英文关键词：

• 摘要：

• 结合当前输液包装材料在临床的应用情况，检索文献重点关注包装材料与抗肿瘤药物的相容性及吸附性的研究。研究抗肿瘤药物与输液包装材料的相容性，根据抗肿瘤药物的特点分析其与包装材料产生相容性的原因，提出合理包装方案。不同的输液包装材料与抗肿瘤药物相容性有别，吸附程度可直接影响药物疗效、引发患者产生药物不良反应。输液包装材料与抗肿瘤药物的相容性对药物稳定性、药物疗效有一定的影响。根据不同结构类型化疗药物的性质，选择合适的输液包装材料，减少药物浓度不必要的流失，避免药物疗效下降及患者输液不良反应的发生。

• 【Abstract】Literatures focusing on the compatibility and adsorbability between antitumor drugs and infusion packaging materials were searched. Compatibility and adsorbability between drugs and materials may have influences on the concentration, stability and property of drugs, which may lead to decrease of curative effect and occurrence of adverse reactions. Reasons of compatibility between drugs and materials were analyzed and optional packing schemes were suggested based on different types of chemotherapeutic drugs in this paper.

  【Key words】Antitumor drugs;Infusion packaging materials;Compatibility;Polyvinyl chloride;Polyolefin thermoplastic elastomer