2018 年第 10 期 第 13 卷

血脂康对围绝经期高脂血症患者血脂代谢的影响

Effect of Xuezhikang on lipid metabolism in perimenopausal women with hyperlipemia

作者：冯妍王以新张佩雪张淼淼康晨瑜

英文作者：

单位：100029首都医科大学附属北京安贞医院全科医疗科（冯妍、王以新、张佩雪、康晨瑜）；100069北京，首都医科大学全科医学系（张淼淼）

英文单位：

关键词：高脂血症；围绝经期；心血管疾病；血脂代谢；血脂康

英文关键词：

• 摘要：

• 【摘要】目的    探讨血脂康对围绝经期高脂血症患者血脂代谢的影响。方法    选取2015年5月至2016年5月首都医科大学附属北京安贞医院全科医疗科门诊年龄在45～55岁围绝经期高脂血症女性患者100例，采用随机数字表法将患者分为观察组（50例）与对照组（50例）。对照组服用阿托伐他汀钙片10 mg，每晚1次；观察组服用血脂康2粒(0.6 g)，早晚各1次；治疗观察期为8周。治疗前后检测患者空腹血糖、血脂、雌二醇、孕酮、睾酮水平。结果    2组治疗前空腹血糖、血脂指标、激素水平比较，差异均无统计学意义（均P＞0.05）。治疗8周后，观察组三酰甘油和极低密度脂蛋白胆固醇水平明显低于对照组［（1.5±0.4）mmol/L比（1.7±0.4）mmol/L、（0.91±0.25）mmol/L比（0.98±0.35）mmol/L］，高密度脂蛋白胆固醇水平明显高于对照组［（1.0±0.4）mmol/L比（0.9±0.4）mmol/L］，雌二醇水平明显高于对照组［（21.9±3.1）ng/L比（17.7±2.4）ng/L］，差异均有统计学意义（均P＜0.05）。结论    血脂康较常规他汀类药物可能通过对雌二醇等雌激素水平产生影响，更全面地改善围绝经期高脂血症患者的脂质代谢。

• 【Abstract】Objective    To investigate the effect of Xuezhikang on lipid metabolism in perimenopausal patients with hyperlipemia. Methods    One hundred perimenopausal patients（40-45 years old） with hyperlipemia were enrolled from May 2015 to May 2016 in Beijing Anzhen Hospital, Capital Medical University. They were randomly divided into observation group(n＝50) and control group(n＝50). The control group took atorvastatin calcium 10 mg every night; the observation group took Xuezhikang 0.6 g, 2 times/d; both groups were treated for 8 weeks. Fasting blood glucose, blood lipid, estradiol, progesterone and testosterone were analyzed. Results    There was no significant difference of fasting blood glucose, blood lipid and hormones between the two groups before treatment（P＞0.05）. After 8 weeks of treatment, levels of triglyceride and very low-density lipoprotein cholesterol in the observation group were significantly lower than those in the control group［（1.5±0.4）mmol/L vs （1.7±0.4）mmol/L, （0.91±0.25）mmol/L vs （0.98±0.35）mmol/L］; high-density lipoprotein cholesterol level in the observation group was significantly higher than that in the control group［（1.0±0.4）mmol/L vs （0.9±0.4）mmol/L］; estradiol level in the observation group was significantly higher than that in the control group［（21.9±3.1）ng/L vs （17.7±2.4）ng/L］（all P＜0.05）. Conclusion    Xuezhikang can more significantly improve lipid metabolism than conventional statins in perimenopausal hyperlipidemia patients, which may be associated with the regulatory effect on estradiol.