2019 年第 3 期 第 14 卷

血浆正五聚蛋白3水平与颈动脉粥样硬化斑块稳定性的相关性研究

Correlation between plasma pentraxins 3 level and carotid atherosclerotic plaque stability

作者：曹端华闫海燕王婷婷韩敬哲郗红艳

英文作者：

单位：053000河北省衡水市，哈励逊国际和平医院神经内一科

英文单位：

关键词：颈动脉粥样硬化斑块；正五聚蛋白3

英文关键词：

• 摘要：

• 【摘要】目的    探讨血浆正五聚蛋白3（PTX3）水平与颈动脉粥样硬化斑块稳定性的相关性。方法    选取2014年1月至2015年12月于哈励逊国际和平医院体检科行健康体检者360人。根据颈动脉超声检查结果分为内膜正常组、内膜增厚组、稳定斑块组及不稳定斑块组。采用全自动酶标仪检测4组的血浆PTX3水平。采用Logistic回归分析血浆PTX3水平与颈动脉粥样硬化斑块稳定性的相关性。结果    4组受试者高血压病史比例、同型半胱氨酸水平差异有统计学意义（P＜0.05）。内膜正常组（205例）、内膜增厚组（42例）、稳定斑块组（61例）、不稳定斑块组（52例）血浆PTX3水平依次增高，分别为（925±114）、（1 025±128）、（1 136±141）、（1 357±158）ng/L，两两比较差异均有统计学意义(均P＜0.05)。Logistic回归分析结果显示血浆PTX3是影响斑块稳定性的危险因素（比值比=0.008，95%置信区间：0.000～0.171，P=0.002）。结论    血浆PTX3是影响颈动脉粥样硬化斑块稳定性的危险因素，血浆PTX3水平越高，斑块越不稳定。

• 【Abstract】Objective    To investigate the correlation between plasma pentraxins 3(PTX3) level and carotid atherosclerotic plaque stability. Methods    A total of 360 people who had physical examination in Harrison International Peace Hospital from January 2014 to December 2015 were enrolled. According to the results of carotid ultrasonography, the patients were divided into normal intima group, intimal thickening group, stable plaque group and unstable plaque group. Plasma level of PTX3 was detected by automatic enzyme labeling instrument. Relation between plasma PTX3 level and carotid atherosclerotic plaque stability was analyzed by logistic regression. Results    There were significant differences of the proportion of hypertension history and the level of serum homocysteine among the four groups(P<0.05). Levels of plasma PTX3 in normal intima group, intimal thickening group, stable plaque group and unstable plaque group were (925±114）,（1 025±128）,（1 136±141） and （1 357±158）ng/L and there were significant differences in paired comparisons(all P<0.05). Logistic regression analysis showed that plasma PTX3 level was a risk factor of the stability of carotid atherosclerotic plaques(odds ratio=0.008, 95% confidence interval: 0.000-0.171, P=0.002）. Conclusion    Plasma PTX3 level is a risk factor affecting the stability of carotid atherosclerotic plaque.