2021 年第 12 期 第 16 卷

中药对阿尔茨海默病鼠模型作用机制的研究进展

Research progress on mechanisms of traditional Chinese medicine in the treatment of Alzheimer′s disease mice model

作者：牛天童刘广志

英文作者：Niu Tiantong Liu Guangzhi

单位：首都医科大学附属北京安贞医院神经内科100029

英文单位：Department of Neurology Beijing Anzhen Hospital Capital Medical University Beijing 100029 China

关键词：阿尔茨海默病；鼠模型；中药；研究进展

英文关键词：Alzheimer′sdisease;Micemodel;TraditionalChinesemedicine;Researchprogress

• 摘要：

• 阿尔茨海默病（AD）是一种中枢神经系统退行性疾病，目前病因不明确，尚无特效药物。中药因具有多靶点、多方式且不良反应少的特点，在AD的治疗上占有明显的优势，受到了广泛关注。为进一步探究中药的作用机制，研究者们将不同的AD动物模型（转基因AD动物模型、非转基因AD动物模型和非人工诱发的AD动物模型）应用到实验中，模拟AD不同的病理学改变，以期为该病的药物研发提供一定的参考。本文对不同的中药对AD鼠模型作用机制的研究进展进行综述。

• Alzheimer′s disease (AD) is a neurodegenerative disease that is difficult to find out the etiology and to be cured with specific drug at present. Traditional Chinese medicine has attracted attention widely because it has obvious advantages in the treatment of AD by view of its characteristics such as multi-target, multi-mode and few adverse reactions. In order to further explore the mechanisms of traditional Chinese medicine, the researchers have applied various AD animal models（transgenic AD animal model, non-transgenic AD animal model and non-artificially induced AD animal model） to the experiment to simulate different pathological changes of AD for the purpose of providing some reference for the drug research and development. Therefore, this article reviews the advance in study on mechanisms of different traditional Chinese medicine components in the treatment of AD mice model.