2021 年第 12 期 第 16 卷

肠道微生物和Toll样受体与帕金森病的相关性研究进展

Research progress on the relationship between gut microbes, Toll-like receptors and Parkinson′s disease

作者：刘蕊1陈丽2

英文作者：Liu Rui1 Chen Li2

单位：1首都医科大学基础医学院2019级长学制临床专业，北京100069；2首都医科大学公共卫生学院劳动卫生与环境卫生学系，北京100069

英文单位：1School of Basic Medical Sciences Grade 2019 Eight Year Program Clinical Medicine Capital Medical University Beijing 100069 China; 2Department of Occupational Health and Environmental Health School of Public Health Capital Medical University Beijing 100069 China

关键词：帕金森病；肠道微生物；微生物-肠-脑轴；Toll样受体

英文关键词：Parkinson′sdisease;Gutmicrobiota;Microbiota-gut-brainaxis;Toll-likereceptors

• 摘要：

• 近年研究发现，帕金森病发病可能与肠道微生物有关。肠道微生物可能通过神经内分泌调节、神经免疫调节和神经调节等方式影响大脑功能，进而导致帕金森病的发病，而Toll样受体在其中扮演了重要的角色。对肠道微生物进行调节或可成为帕金森病等神经退行性疾病的新兴治疗方向。本文对肠道微生物紊乱和Toll样受体与帕金森病的相关性研究进展进行综述。

• In recent years, studies have shown that Parkinson′s disease may be associated with gut microbiota, which influences the function of brain through neuroendocrine regulation, neuroimmunology regulation and neuromodulation, further contributing to the onset of Parkinson′s disease. During this process, Toll-like receptors play a crucial role. Regulation of gut microbiota opens the possibility for new treatment for Parkinson′s disease. This review summarizes the research progress on the role of gut microbiota disorder and Toll-like receptors in pathogenesis of Parkinson′s disease.