2022 年第 12 期 第 17 卷

NOD样受体蛋白3炎症小体的激活及其在糖尿病相关疾病中作用的研究进展

Research progress of NOD-like receptor protein 3 inflammasome activation and its role in diabetes-related diseases

作者：禚昭钦1陈丽1周忠志2洪恺祺1陆欣怡1段博方1韩欣秀1郭佳鑫1黄新灵2

英文作者：Zhuo Zhaoqin1 Chen Li1 Zhou Zhongzhi2 Hong Kaiqi1 Lu Xinyi1 Duan Bofang1 Han Xinxiu1 Guo Jiaxin1 Huang Xinling2

单位：1湖南中医药大学医学院，长沙410208；2湖南中医药大学第一附属医院烧伤疮疡整形科，长沙410007

英文单位：1Medical School Hunan University of Chinese Medicine Changsha 410208 China; 2Department of Burn and Ulcer Plastic Surgery the First Affiliated Hospital of Hunan University of Chinese Medicine Changsha 410007 China

关键词：糖尿病；NOD样受体蛋白3炎症小体；线粒体；内质网应激

英文关键词：Diabetesmellitus;NOD-likereceptorprotein3inflammasome;Mitochondrion;Endoplasmicreticulumstress

• 摘要：

• NOD样受体蛋白3（NLRP3）炎症小体是炎症反应中最具有代表性的一种三聚体复合物，它不仅是炎症反应的“感受器”，亦是炎症反应的“调节器”。糖尿病高糖环境下可通过多种机制激活NLRP3炎症小体，引发炎症反应，进而影响糖尿病相关疾病的发生发展。近年来，NLRP3炎症小体引起的炎症反应在糖尿病相关疾病中的作用越来越受到重视。本文主要对NLRP3炎症小体的激活及其在糖尿病相关疾病中的作用进行阐述。

• NOD-like receptor protein 3 (NLRP3) inflammasome is the most representative trimer complex in inflammation. It is not only the "receptor" of inflammation, but also the "regulator" of inflammation. Under the high glucose environment of diabetes mellitus, NLRP3 inflammasome can be activated through various mechanisms, which may lead to inflammation and further affect the development of diabetes-related diseases. In recent years, the role of inflammation induced by NLRP3 inflammasome in diabetes-related diseases has attracted more and more attention. This paper mainly expounds the activation of NLRP3 inflammasome and its role in diabetes-related diseases.