2023 年第 8 期 第 18 卷

大动脉炎冠状动脉受累的诊治新进展

Research progress of coronary artery involvements in Takayasu arteritis

作者：任颖琦1潘丽丽2杜娟2李涛涛2

英文作者：Ren Yingqi1 Pan Lili2 Du Juan2 Li Taotao2

单位：1首都医科大学第六临床医学院，北京100029；2首都医科大学附属北京安贞医院风湿免疫科，北京100029

英文单位：1The Sixth Clinical Medical College Capital Medical University Beijing 100029 China; 2Department of Rheumatology and Immunology Beijing Anzhen Hospital Capital Medical University Beijing 100029 China

关键词：大动脉炎；冠状动脉；诊断；治疗；进展

英文关键词：Takayasuarteritis;Coronaryartery;Diagnosis;Treatment;Progress

• 摘要：

• 大动脉炎是一种慢性、肉芽肿性大血管炎，主要累及主动脉及其分支，主动脉的二级分支如肺动脉和冠状动脉也可能受累。在大动脉炎患者中，冠状动脉受累并不罕见，是导致其预后不良和死亡率高的重要不利因素。目前系统描述大动脉炎冠状动脉受累情况的有关文献报道较少。本文总结了大动脉炎累及冠状动脉的发病机制、危险因素、临床特征、实验室及影像学特点、与冠状动脉粥样硬化区别和治疗方法，旨在为大动脉炎冠状动脉病变的诊断、防治和改善预后提供依据。

• Takayasu arteritis (TAK) is a chronic, granulomatous, large-vessel vasculitis mainly affecting the aorta and its major branches. The secondary branches of the aorta, such as the pulmonary artery and coronary artery, can also be involved. Coronary involvement is not rare in patients with TAK and it is a serious adverse factor associated with a poor prognosis and increased mortality in patients with TAK. At present, the systematic description of coronary artery involvement with TAK is rarely reported. This paper summarizes the pathogenesis, risk factors, clinical features, laboratory and imaging features, the difference between TAK and coronary atherosclerosis and the treatment of coronary artery involvement in patient with TAK. In order to provide evidence for the diagnosis, prevention and treatment of coronary artery involvement in TAK.