2024 年第 5 期 第 0 卷

柴胡汤联合草酸艾司西酞普兰对围绝经期抑郁症患者心理弹性和症状及激素水平的影响分析

Impacts of Chaihu decoction combined with escitalopram oxalate on psychological resilience, symptoms and hormone level in patients with perimenopausal depression

作者：陶珺1 梅妍2 李思1 王达1 包晗1 刘梦珂1

英文作者：Tao Jun1 Mei Yan2 Li Si1 Wang Da1 Bao Han1 Liu Mengke1

单位：1天津中医药大学，天津301617；2天津中医药研究院附属医院心身疾病科，天津300120

英文单位：1Tianjin University of Traditional Chinese Medicine Tianjin 301617 China; 2Department of Psychosomatic Diseases Affiliated Hospital of Tianjin Institute of Traditional Chinese Medicine Tianjin 300120 China

关键词：围绝经期抑郁症；草酸艾司西酞普兰；柴胡汤

英文关键词：Perimenopausaldepression;Escitalopramoxalate;Chaihudecoction

• 摘要：

• 目的  探究柴胡汤联合草酸艾司西酞普兰对围绝经期抑郁症患者心理弹性、症状及激素水平的影响。方法  选取2021年6月至2022年11月天津中医药研究院附属医院收治的98例围绝经期抑郁症患者为研究对象，采用随机数字表法分为对照组和观察组，各49例。对照组给予草酸艾司西酞普兰治疗，观察组在对照组基础上给予柴胡汤治疗。2组均连续治疗2个月。比较2组治疗前后心理弹性、症状以及血清激素、5-羟色胺、脑源性神经营养因子（BDNF）水平。结果  治疗后，2组心理弹性量表评分、5-羟色胺、BDNF、雌激素水平均高于治疗前，且观察组均高于对照组［81（74,85）分比73（70,77）分、（36.5±3.7）ng/L比（32.2±3.4）ng/L、（18.7±1.9）ng/L比（15.4±1.7）ng/L、（26.3±2.8）ng/L比（22.1±2.4）ng/L］（均P<0.05）；2组Kupperman评分、汉密尔顿抑郁量表评分、促黄体生成素、卵泡刺激素水平均低于治疗前，且观察组均低于对照组（均P<0.05）。结论  柴胡汤联合草酸艾司西酞普兰治疗围绝经期抑郁症可有效改善患者心理弹性水平、缓解症状并降低相关激素水平。

• Objective  To investigate the impacts of Chaihu decoction combined with escitalopram oxalate on psychological resilience, symptoms, and hormone level in patients with perimenopausal depression. Methods  Totally 98 patients with perimenopausal depression admitted to Affiliated Hospital of Tianjin Institute of Traditional Chinese Medicine from June 2021 to November 2022 were enrolled. Patients were divided into control group and observation group, with 49 cases each, by the random number table method. The control group was treated with escitalopram oxalate, while the observation group was treated with Chaihu decoction based on the control group. Both groups were treated for 2 months. The psychological resilience, symptoms and serum levels of hormone, 5-hydroxytryptamine and brain-derived neurotrophic factor (BDNF) were compared between the two groups before and after treatment. The clinical efficacy of patients was recorded. Results  After treatment, the Connor-Davidson Resilience Scale score, levels of 5-hydroxytryptamine, BDNF, and estrogen in both groups were increased, and the above indicators in the observation group were higher than those in the control group ［81（74,85） vs 73（70,77）,（36.5±3.7）ng/L vs （32.2±3.4）ng/L,（18.7±1.9）ng/L vs （15.4±1.7）ng/L,（26.3±2.8）ng/L vs （22.1±2.4）ng/L］(all P<0.05). After treatment, the Kupperman score, Hamilton Depression Scale score, luteinizing hormone and follicle-stimulating hormone levels in both groups were obviously reduced, and the above indicators in the observation group were lower than those in the control group (all P<0.05). Conclusion  Chaihu decoction combined with escitalopram oxalate can effectively improve the psychological resilience level of patients with perimenopausal depression, alleviate symptoms, and reduce hormone level.