2024 年第 5 期 第 0 卷

原发性膜性肾病自身抗原的研究进展

Research progress of autoantigens associated with primary membranous nephropathy

作者：邵丹丹 何伟春

英文作者：Shao Dandan He Weichun

单位：南京医科大学第二附属医院肾脏病中心，南京210000

英文单位：Center for Kidney Disease the Second Affiliated Hospital of Nanjing Medical University Nanjing 210000 China

关键词：原发性膜性肾病；自身抗原；自身抗体

英文关键词：Primarymembranousnephropathy;Autoantigens;Autoantibodies

• 摘要：

• 原发性膜性肾病（PMN）是一种自身免疫性肾小球疾病。目前，研究人员对其自身抗原的研究给予了广泛关注。继M型磷脂酶A2受体和1型血小板反应蛋白域7A后，随着激光显微切割肾小球联合质谱分析等技术的应用，研究者们又陆续发现了5种PMN自身抗原及相关抗体，这些自身抗原及抗体的发现极大地推进了对PMN发病机制和临床实践的认识。本文对PMN自身抗原的研究进展进行综述。

• Primary membranous nephropathy (PMN) is an autoimmune glomerular disease. At present, researchers have paid much attention to the study of its autoantigens. Following the M-type phospholipase A2 receptor and type 1 platelet-reactive protein domain 7A, with the application of laser microdissection of glomeruli combined with mass spectrometry, researchers have found five kinds of PMN autoantigens and related antibodies. The discovery of these autoantigens and antibodies has greatly advanced the understanding of PMN pathogenesis and clinical practice. This article reviews the research progress of PMN autoantigens.