2025 年第 4 期 第 20 卷

健脾补血颗粒联合三维亚铁咀嚼片治疗妊娠期缺铁性贫血的临床研究

Clinical study of Jianpi Buxue granules combined with trivitamins ferrous chewable tablets in the treatment of iron deficiency anemia during pregnancy

作者：邵娟1李文婷2同虹宇1

英文作者：Shao Juan1 Li Wenting2 Tong Hongyu1

单位：1陕西中医药大学附属中西医结合医院陕西省西安市第五医院妇产科，西安710082；2陕西中医药大学第二附属医院产科，咸阳712000

英文单位：1Department of Obstetrics and Gynecology the Affiliated Hospital of Integrated Traditional Chinese and Western Medicine Shaanxi University of Chinese Medicine Xi′an Fifth Hospital Shaanxi Province Xi′an 710082 China; 2Department of Obstetrics the Second Affiliated Hospital of Shaanxi University of Chinese Medicine Xianyang 712000 China

关键词：妊娠期缺铁性贫血；健脾补血颗粒；三维亚铁咀嚼片

英文关键词：Irondeficiencyanemiaduringpregnancy;JianpiBuxuegranules;Trivitaminsferrouschewabletablets

• 摘要：

• 目的 探讨健脾补血颗粒联合三维亚铁咀嚼片治疗妊娠期缺铁性贫血的效果。方法 选取2022年3月至2023年12月陕西中医药大学附属中西医结合医院收治的168例妊娠期缺铁性贫血患者作为研究对象。采用随机数字表法将168例妊娠期缺铁性贫血患者分为对照组和观察组，每组84例。对照组给予三维亚铁咀嚼片治疗，观察组在对照组基础上给予健脾补血颗粒治疗。2组均连续治疗1个月。比较2组治疗效果、贫血指标、铁代谢指标、不良反应发生情况。结果 观察组总有效率高于对照组［95.2%（80/84）比85.7%（72/84）］，差异具有统计学意义（χ2=4.421，P=0.035）。治疗1个月后，2组血红蛋白、红细胞平均体积、红细胞平均血红蛋白含量均高于/大于治疗前，且观察组均高于/大于对照组，差异均有统计学意义（均P＜0.05）。治疗1个月后，2组铁蛋白水平均高于治疗前，血清可溶性转铁蛋白受体和总铁结合力均低于治疗前，且观察组铁蛋白水平高于对照组，血清可溶性转铁蛋白受体和总铁结合力均低于对照组，差异均有统计学意义（均P＜0.05）。观察组和对照组不良反应发生率比较［7.1%（6/84）比4.8%（4/84）］，差异无统计学意义（χ2=0.425，P=0.514）。结论 健脾补血颗粒联合三维亚铁咀嚼片治疗妊娠期缺铁性贫血的效果更佳，能有效改善血红蛋白、平均红细胞体积、平均红细胞血红蛋白含量，补充机体的铁储备，改善铁代谢指标，且不良反应少而轻微。

• Objective To investigate the effect of Jianpi Buxue granules combined with trivitamins ferrous chewable tablets in the treatment of iron deficiency anemia during pregnancy. Methods A total of 168 patients with iron deficiency anemia during pregnancy admitted to the Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Shaanxi University of Chinese Medicine from March 2022 to December 2023 were selected as the research objects. A total of 168 patients with iron deficiency anemia during pregnancy were divided into control group and observation group by random number table method, with 84 cases in each group. The control group was treated with trivitamins ferrous chewable tablets, and the observation group was treated with Jianpi Buxue granule on the basis of the control group. Both groups were treated for 1 month. The therapeutic effects, anemia indexes, iron metabolism indexes, and adverse reactions were compared between the two groups. Results The total effective rate of the observation group was higher than that of the control group ［95.2%(80/84) vs 85.7%(72/84)］(χ2=4.421, P=0.035). After 1 month of treatment, the levels of hemoglobin, mean corpuscular volume and mean corpuscular hemoglobin in the two groups were higher/greater than those before treatment, and those in the observation group were higher/greater than those in the control group (all P＜0.05). After 1 month of treatment, the ferritin levels of the two groups were higher than those before treatment, and the serum soluble transferrin receptor and total iron binding capacity were lower than those before treatment; the ferritin level of the observation group was higher than that of the control group, and the serum soluble transferrin receptor and total iron binding capacity were lower than those of the control group (all P＜0.05). There was no significant difference in the incidence of adverse reactions between the observation group and the control group ［7.1%(6/84) vs 4.8%(4/84)］(χ2=0.425, P=0.514). Conclusion Jianpi Buxue granule combined with trivitamins ferrous chewable tablets is more effective in the treatment of iron deficiency anemia during pregnancy, which can effectively improve hemoglobin, mean corpuscular volume and mean corpuscular hemoglobin level, supplement the body′s iron reserve, improve iron metabolism indicators, and has few and mild adverse reactions.